Top Natural Supplements for Longevity

Aging is an inevitable part of life, but we have the power to influence how gracefully we age. By incorporating natural compounds. The aging process can be attributed to two main factors: increased inflammation and the loss of control over reactive oxygen species (ROS). Helping cells modulate inflammatory processes and ROS can allow us to prolong our lives healthily. 

Resveratrol 

Resveratrol is a polyphenol with a significant impact on a group of proteins called sirtuins. Sirtuins protect both mitochondrial DNA and nuclear DNA, maintaining the integrity of the cells’ genetic material. Imagine sirtuins as the security guards of your cells, keeping everything in check and ensuring everything runs smoothly. Resveratrol can be found in the skin of grapes, blueberries, raspberries, mulberries, and peanuts, making these foods great additions to your diet. It is also available as a dietary supplement in capsule or tablet form. 

Nicotinamide Riboside 

This precursor of the coenzyme NAD, derived from vitamin B3, can increase NAD levels in cells. Think of NAD as your body’s energy currency; increasing it is like boosting your bank balance, giving your cells the resources they need to function optimally. Studies have shown that increasing NAD can extend lifespan in several types of animals. You can find nicotinamide riboside as a supplement, often marketed as Niagen, or in some fortified foods and beverages. 

Luteolin 

Luteolin is a flavonoid that acts directly on a specific protein (Nrf2) that modulates all endogenous antioxidant mechanisms in cells. Consider Nrf2 as the body’s internal fire brigade, controlling and putting out the fires of inflammation and oxidative stress within cells. Luteolin is naturally present in foods such as celery, thyme, green peppers, and chamomile tea, making these foods excellent for supporting healthy aging. Supplements are also available for those looking to increase their intake. 

Astaxanthin 

Astaxanthin is a carotenoid with a crucial role in protecting mitochondrial membranes, promoting a more homogeneous transfer of electrons, and shielding against the damaging effects of free radicals, especially from UV rays. This is why NASA includes astaxanthin in the diet of astronauts on space missions, ensuring they remain protected even in harsh environments. You can find astaxanthin in microalgae, yeast, salmon, trout, krill, shrimp, crayfish, and the feathers of some birds. It can also be taken as a supplement. 

Conclusion 

These powerful substances, found in everyday foods like grapes, celery, and seafood, or available as supplements, can help protect our cells’ genetic material, boost cellular energy, and maintain optimal cell function. Remember, while these nutrients offer promising benefits, they work best as part of a balanced diet and healthy lifestyle. Always consult with a healthcare professional before starting any new supplement to ensure it fits your individual health needs. Embrace these natural tools to help extend not just the length of your life, but the quality of it, promoting vitality and health well into your later years. 

References 

• BARGER, J. L. et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE. 3(6): e2264, 2008. 
• CSISZAR, A. et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol. July; 297(1): H13-H20, 2009. 
• IMAI, S. “Clocks” in NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochimica et Biophysica Acta. xxx xxx-xxx, 2009. 
• IMAI, S. The NAD World: A new systemic regulatory network for metabolism and aging – SIRT1, systemic NAD biosynthesis, and their importance. Cell Biochem Biophys. 53(2): 65-74, 2009. 
• PARK JS, CHYUN JH, KIM YK, LINE LL, AND CHEW BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond). 2010; 7: 18. 
• NISHIDA Y, NAWAZ A, KADO T, TAKIKAWA A, IGARASHI Y, ONOGI Y, et al. Astaxanthin stimulates mitochondrial biogenesis in insulin-resistant muscle via activation of AMPK pathway. J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):241-258. 
• Gendrisch F, et al. Luteolin as a modulator of skin aging and inflammation. Biofactors. 2021 Mar;47(2):170-180. 
• Huang L, et al. Immunopharmacological Activities of Luteolin in Chronic Diseases. Int J Mol Sci. 2023 Jan 21;24(3):2136.